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Mainstream BBC Health 18 hours ago

'World-first' vaccine designed by artificial intelligence

'World-first' vaccine designed 7 hours agoShareSaveAdd as preferred on Google James GallagherHealth and science correspondent Artificial intelligence has been used to develop a "fundamentally new" type of vaccine that could protect against large swathes of viruses and prevent pandemics, say researchers. The team at the University of Cambridge say it is the first time a vaccine's key component has been designed entirely . The vaccine was engineered to work on all coronaviruses which would include all Covid variants and viruses that infect animals, but could start the next pandemic. The work is still in the early stages, but the team is already developing separate vaccines that could tackle flu and Ebola. Vaccines teach our bodies how to spot an infection to increase our chances of fighting it off. But some viruses are adept at changing their appearance – or mutating – so vaccines can quickly go out of date. It's why Covid and winter flu vaccines need to be regularly updated. "We're always behind," said Prof Jonathan Heeney, from the University of Cambridge, adding "what we're trying to do is get ahead of the curve" and so far ahead they could protect against new outbreaks or pandemics. Vaccines played a crucial role in the pandemic, but needed to be designed from scratch and then updated as the virus mutated How does it work? Normally vaccines are designed using a current strain of a virus. The Cambridge researchers took known genetic codes – the instruction manuals of life – from a range of coronaviruses that had been recorded . These genetic codes were analysed . It then designed a "super-antigen" that could train the immune system in such a way it gave protection against the whole family of viruses – even if they mutated or a new infection jumped from animals to people. Antigens are the critical components of vaccines as this is what the immune system learns to attack. Heeney said this was the first time an antigen designed . He said the technology was "surprising all of us" and it was "amazing what we can do with it for the good of humanity". Heeney told BBC News: "This is about making vaccines that protect us, not just from today's viruses, but protect us from what can cause the next outbreak or disease. "This is a fundamental shift in how we prepare for pandemics." Bats are one source of coronaviruses The trials, in 39 people, were designed to assess if such vaccines were safe.

Original story by BBC Health View original source

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